Toxicity of overexpressed MeCP2 is independent of HDAC3 activity

Duplication of the X-linked MECP2 gene causes a severe neurological syndrome whose molecular basis is poorly understood. To determine the contribution of known functional domains to overexpression toxicity, we engineered a mouse model that expresses wild-type or mutated MeCP2 from the Mapt (Tau) loc...

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Vydáno v:Genes Dev
Hlavní autoři: Koerner, Martha V., FitzPatrick, Laura, Selfridge, Jim, Guy, Jacky, De Sousa, Dina, Tillotson, Rebekah, Kerr, Alastair, Sun, Zheng, Lazar, Mitchell A., Lyst, Matthew J., Bird, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295171/
https://ncbi.nlm.nih.gov/pubmed/30463906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.320325.118
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