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Toxicity of overexpressed MeCP2 is independent of HDAC3 activity
Duplication of the X-linked MECP2 gene causes a severe neurological syndrome whose molecular basis is poorly understood. To determine the contribution of known functional domains to overexpression toxicity, we engineered a mouse model that expresses wild-type or mutated MeCP2 from the Mapt (Tau) loc...
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| Publicado en: | Genes Dev |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6295171/ https://ncbi.nlm.nih.gov/pubmed/30463906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.320325.118 |
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