Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Genome editing in hematopoietic stem and progenitor cells (HSPCs) is a promising novel technology for the treatment of many human diseases. Here, we evaluated whether the disruption of the C-C chemokine receptor 5 (CCR5) locus in pigtailed macaque HSPCs by zinc finger nucleases (ZFNs) was feasible....

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Peterson, Christopher W., Wang, Jianbin, Norman, Krystin K., Norgaard, Zachary K., Humbert, Olivier, Tse, Collette K., Yan, Jenny J., Trimble, Richard G., Shivak, David A., Rebar, Edward J., Gregory, Philip D., Holmes, Michael C., Kiem, Hans-Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2016
Ämnen:
Gene Therapy
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874223/
https://ncbi.nlm.nih.gov/pubmed/26980728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-672337
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