Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Genome editing in hematopoietic stem and progenitor cells (HSPCs) is a promising novel technology for the treatment of many human diseases. Here, we evaluated whether the disruption of the C-C chemokine receptor 5 (CCR5) locus in pigtailed macaque HSPCs by zinc finger nucleases (ZFNs) was feasible....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Peterson, Christopher W., Wang, Jianbin, Norman, Krystin K., Norgaard, Zachary K., Humbert, Olivier, Tse, Collette K., Yan, Jenny J., Trimble, Richard G., Shivak, David A., Rebar, Edward J., Gregory, Philip D., Holmes, Michael C., Kiem, Hans-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874223/
https://ncbi.nlm.nih.gov/pubmed/26980728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-672337
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados