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MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells

Pre-clinical feasibility, safety, and efficacy testing of hematopoietic stem cell (HSC)-mediated gene therapy approaches is commonly performed in large animal models such as nonhuman primates (NHPs). Here we wished to determine whether mouse models would allow engraftment of NHP HSPCs which would en...

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Bibliografische gegevens
Gepubliceerd in:Exp Hematol
Hoofdauteurs: Radtke, Stefan, Chan, Yan-Yi, Sippel, Trisha R., Kiem, Hans-Peter, Rongvaux, Anthony
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719784/
https://ncbi.nlm.nih.gov/pubmed/30590092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.12.003
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