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MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells

Pre-clinical feasibility, safety, and efficacy testing of hematopoietic stem cell (HSC)-mediated gene therapy approaches is commonly performed in large animal models such as nonhuman primates (NHPs). Here we wished to determine whether mouse models would allow engraftment of NHP HSPCs which would en...

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Detalhes bibliográficos
Publicado no:Exp Hematol
Main Authors: Radtke, Stefan, Chan, Yan-Yi, Sippel, Trisha R., Kiem, Hans-Peter, Rongvaux, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719784/
https://ncbi.nlm.nih.gov/pubmed/30590092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2018.12.003
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