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Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
Engineered nucleases have transformed biological research and offer great therapeutic potential by enabling the straightforward modification of desired genomic sequences. While many nuclease platforms have proven functional, all can produce unanticipated off-target lesions and have difficulty discri...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4729830/ https://ncbi.nlm.nih.gov/pubmed/26738816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10194 |
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