Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

Engineered nucleases have transformed biological research and offer great therapeutic potential by enabling the straightforward modification of desired genomic sequences. While many nuclease platforms have proven functional, all can produce unanticipated off-target lesions and have difficulty discri...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Oakes, Benjamin L., Xia, Danny F., Rowland, Elizabeth F., Xu, Denise J., Ankoudinova, Irina, Borchardt, Jennifer S., Zhang, Lei, Li, Patrick, Miller, Jeffrey C., Rebar, Edward J., Noyes, Marcus B.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729830/
https://ncbi.nlm.nih.gov/pubmed/26738816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10194
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