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DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation
Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells. The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instability and chromosomal translocations, leading to t...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107202/ https://ncbi.nlm.nih.gov/pubmed/21655080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002080 |
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