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Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4/ligase IV during chromosomal translocation formation

Chromosomal translocations in hematologic and mesenchymal tumors form overwhelmingly by nonhomologous end-joining (NHEJ). Canonical NHEJ, essential for the repair of radiation-induced and some programmed double-strand breaks (DSBs), requires the Xrcc4/ligase IV complex. For other DSBs, the requireme...

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Detalhes bibliográficos
Main Authors: Simsek, Deniz, Jasin, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893185/
https://ncbi.nlm.nih.gov/pubmed/20208544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1773
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