A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart

Selective inhibition of disease-related proteins underpins the majority of successful drug–target interactions. However, development of effective antagonists is often hampered by targets that are not druggable using conventional approaches. Here, we apply engineered zinc-finger protein transcription...

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Bibliographic Details
Main Authors: Zhang, H Steve, Liu, Dingang, Huang, Yan, Schmidt, Stefan, Hickey, Reed, Guschin, Dmitry, Su, Haili, Jovin, Ion S, Kunis, Mike, Hinkley, Sarah, Liang, Yuxin, Hinh, Linda, Spratt, S Kaye, Case, Casey C, Rebar, Edward J, Ehrlich, Barbara, Gregory, Philip D, Giordano, Frank J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412484/
https://ncbi.nlm.nih.gov/pubmed/22828502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.80
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