A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart

Selective inhibition of disease-related proteins underpins the majority of successful drug–target interactions. However, development of effective antagonists is often hampered by targets that are not druggable using conventional approaches. Here, we apply engineered zinc-finger protein transcription...

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Główni autorzy: Zhang, H Steve, Liu, Dingang, Huang, Yan, Schmidt, Stefan, Hickey, Reed, Guschin, Dmitry, Su, Haili, Jovin, Ion S, Kunis, Mike, Hinkley, Sarah, Liang, Yuxin, Hinh, Linda, Spratt, S Kaye, Case, Casey C, Rebar, Edward J, Ehrlich, Barbara, Gregory, Philip D, Giordano, Frank J
Format: Artigo
Język:Inglês
Wydane: Nature Publishing Group 2012
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Original Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412484/
https://ncbi.nlm.nih.gov/pubmed/22828502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.80
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