Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

We designed and engineered mitochondrially targeted obligate heterodimeric zinc finger nucleases (mtZFNs) for site-specific elimination of pathogenic human mitochondrial DNA (mtDNA). We used mtZFNs to target and cleave mtDNA harbouring the m.8993T>G point mutation associated with neuropathy, atax...

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Main Authors: Gammage, Payam A, Rorbach, Joanna, Vincent, Anna I, Rebar, Edward J, Minczuk, Michal
Formáid: Artigo
Teanga:Inglês
Foilsithe: Backwell Publishing Ltd 2014
Ábhair:
Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992073/
https://ncbi.nlm.nih.gov/pubmed/24567072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303672
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