Discovering and developing PI3 kinase inhibitors for cancer: Rapid progress through academic-biotech-pharma interactions

Por Raynaud, Florence I, Workman, Paul
Publicado em 2011

Drugging the PI3 Kinome: From Chemical Tools to Drugs in the Clinic

Por Workman, Paul, Clarke, Paul A, Raynaud, Florence I, van Montfort, Rob LM
Publicado em 2010

A Phase I/II Study of a 72-h Continuous Infusion of Etoposide in Advanced Soft Tissue Sarcoma

Por Crawley, Charles R., Judson, Ian R., Verrill, Mark, Hill, Catherine, Raynaud, Florence I.
Publicado em 1997

The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase α Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy

Por Al-Saffar, Nada M. S., Jackson, L. Elizabeth, Raynaud, Florence I., Clarke, Paul A., de Molina, Ana Ramírez, Lacal, Juan C., Workman, Paul, Leach, Martin O.
Publicado em 2010

Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species

Por Wood, Francesca L., Shepherd, Sam, Hayes, Angela, Liu, Manjuan, Grira, Katia, Mok, Yi, Atrash, Butrus, Faisal, Amir, Bavetsias, Vassilios, Linardopoulos, Spiros, Blagg, Julian, Raynaud, Florence I.
Publicado no Eur J Pharm Sci (2019)

Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution

Por Hayes, Angela, Mok, N. Yi, Liu, Manjuan, Thai, Ching, Henley, Alan T., Atrash, Butrus, Lanigan, Rachel M., Sejberg, Jimmy, Le Bihan, Yann-Vaï, Bavetsias, Vassilios, Blagg, Julian, Raynaud, Florence I.
Publicado no Xenobiotica (2016)

Erratum to: investigation of metabolites for estimating blood deposition time

Por Lech, Karolina, Liu, Fan, Davies, Sarah K., Ackermann, Katrin, Ang, Joo Ern, Middleton, Benita, Revell, Victoria L., Raynaud, Florence I., Hoveijn, Igor, Hut, Roelof A., Skene, Debra J., Kayser, Manfred
Publicado no Int J Legal Med (2017)

The Aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo

Por Faisal, Amir, Vaughan, Lynsey, Bavetsias, Vassilios, Sun, Chongbo, Atrash, Butrus, Avery, Sian, Jamin, Yann, Robinson, Simon P., Workman, Paul, Blagg, Julian, Raynaud, Florence I., Eccles, Suzanne A., Chesler, Louis, Linardopoulos, Spiros
Publicado no Mol Cancer Ther (2011)

Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library

Por Welford, Amanda J, Caldwell, John J., Liu, Manjuan, Richards, Meirion, Brown, Nathan, Lomas, Cara, Tizzard, Graham J., Pitak, Mateusz B., Coles, Simon J., Eccles, Suzanne A., Raynaud, Florence I., Collins, Ian
Publicado no Chemistry (2016)

Differences in signaling patterns on PI3K inhibition reveal context specificity in KRAS mutant cancers

Por Stewart, Adam, Coker, Elizabeth A, Pölsterl, Sebastian, Georgiou, Alexandros, Minchom, Anna R, Carreira, Suzanne, Cunningham, David, O’Brien, Mary ER, Raynaud, Florence I, de Bono, Johann S, Al-Lazikani, Bissan, Banerji, Udai
Publicado no Mol Cancer Ther (2019)

Effect of sleep deprivation on the human metabolome

Por Davies, Sarah K., Ang, Joo Ern, Revell, Victoria L., Holmes, Ben, Mann, Anuska, Robertson, Francesca P., Cui, Nanyi, Middleton, Benita, Ackermann, Katrin, Kayser, Manfred, Thumser, Alfred E., Raynaud, Florence I., Skene, Debra J.
Publicado em 2014

Enhanced efficacy of IGF1R inhibition in paediatric glioblastoma by combinatorial targeting of PDGFRα/β

Por Bielen, Aleksandra, Perryman, Lara, Box, Gary M., Valenti, Melanie, de Haven Brandon, Alexis, Martins, Vanessa, Jury, Alexa, Popov, Sergey, Gowan, Sharon, Jeay, Sebastien, Raynaud, Florence I., Hofmann, Francesco, Hargrave, Darren, Eccles, Suzanne A., Jones, Chris
Publicado em 2011

7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the p...

Por Bavetsias, Vassilios, Pérez-Fuertes, Yolanda, McIntyre, Patrick J., Atrash, Butrus, Kosmopoulou, Magda, O’Fee, Lisa, Burke, Rosemary, Sun, Chongbo, Faisal, Amir, Bush, Katherine, Avery, Sian, Henley, Alan, Raynaud, Florence I., Linardopoulos, Spiros, Bayliss, Richard, Blagg, Julian
Publicado no Bioorg Med Chem Lett (2015)

Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition

Por Bielen, Aleksandra, Box, Gary, Perryman, Lara, Bjerke, Lynn, Popov, Sergey, Jamin, Yann, Jury, Alexa, Valenti, Melanie, Brandon, Alexis de Haven, Martins, Vanessa, Romanet, Vincent, Jeay, Sebastien, Raynaud, Florence I., Hofmann, Francesco, Robinson, Simon P., Eccles, Suzanne A., Jones, Chris
Publicado em 2012

Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo

Por Renshaw, Jane, Taylor, Kathryn R., Bishop, Ryan, Valenti, Melanie, De Haven Brandon, Alexis, Gowan, Sharon, Eccles, Suzanne A., Ruddle, Ruth R., Johnson, Louise D., Raynaud, Florence I., Selfe, Joanna L., Thway, Khin, Pietsch, Torsten, Pearson, Andrew D., Shipley, Janet
Publicado em 2013

Selective FLT3 inhibition of FLT3-ITD(+) acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Por Moore, Andrew S., Faisal, Amir, de Castro, David Gonzalez, Bavetsias, Vassilios, Sun, Chongbo, Atrash, Butrus, Valenti, Melanie, de Haven Brandon, Alexis, Avery, Sian, Mair, Debbie, Mirabella, Fabio, Swansbury, John, Pearson, Andrew D.J., Workman, Paul, Blagg, Julian, Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros
Publicado em 2012

Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

Por Bavetsias, Vassilios, Faisal, Amir, Crumpler, Simon, Brown, Nathan, Kosmopoulou, Magda, Joshi, Amar, Atrash, Butrus, Pérez-Fuertes, Yolanda, Schmitt, Jessica A., Boxall, Katherine J., Burke, Rosemary, Sun, Chongbo, Avery, Sian, Bush, Katherine, Henley, Alan, Raynaud, Florence I., Workman, Paul, Bayliss, Richard, Linardopoulos, Spiros, Blagg, Julian
Publicado em 2013

Plasma metabolomic changes following PI3K inhibition as pharmacodynamic biomarkers: preclinical discovery to Phase I trial evaluation

Por Ang, Joo Ern, Pandher, Rupinder, Ang, Joo Chew, Asad, Yasmin J, Henley, Alan, Valenti, Melanie, Box, Gary, de haven Brandon, Alexis, Baird, Richard R., Friedman, Lori, Derynck, Mika, Vanhaesebroeck, Bart, Eccles, Suzanne A, Kaye, Stan B, Workman, Paul, de Bono, Johann S, Raynaud, Florence I
Publicado no Mol Cancer Ther (2016)

Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

Por McHardy, Tatiana, Caldwell, John J., Cheung, Kwai-Ming, Hunter, Lisa J., Taylor, Kevin, Rowlands, Martin, Ruddle, Ruth, Henley, Alan, de Haven Brandon, Alexis, Valenti, Melanie, Davies, Thomas G., Fazal, Lynsey, Seavers, Lisa, Raynaud, Florence I., Eccles, Suzanne A., Aherne, G. Wynne, Garrett, Michelle D., Collins, Ian
Publicado em 2010

Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate fo...

Por Bavetsias, Vassilios, Crumpler, Simon, Sun, Chongbo, Avery, Sian, Atrash, Butrus, Faisal, Amir, Moore, Andrew S., Kosmopoulou, Magda, Brown, Nathan, Sheldrake, Peter W., Bush, Katherine, Henley, Alan, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Raynaud, Florence I., Workman, Paul, Eccles, Suzanne A., Bayliss, Richard, Linardopoulos, Spiros, Blagg, Julian
Publicado em 2012