Differences in signaling patterns on PI3K inhibition reveal context specificity in KRAS mutant cancers

It is increasingly appreciated that drug response to different cancers driven by the same oncogene is different and may relate to differences in re-wiring of signal transduction. We aimed to study differences in dynamic signaling changes within mutant KRAS (KRAS(MT)), non-small cell lung cancer (NSC...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Stewart, Adam, Coker, Elizabeth A, Pölsterl, Sebastian, Georgiou, Alexandros, Minchom, Anna R, Carreira, Suzanne, Cunningham, David, O’Brien, Mary ER, Raynaud, Florence I, de Bono, Johann S, Al-Lazikani, Bissan, Banerji, Udai
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679718/
https://ncbi.nlm.nih.gov/pubmed/31262731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0727
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