A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments

We investigated PD-L1 changes in response to MEK and AKT inhibitors in KRAS mutant lung adenocarcinoma (adeno-NSCLC). PD-L1 expression was quantified using immunofluorescence and co-culture with a jurkat cell-line transfected with NFAT-luciferase was used to study if changes in PD-L1 expression in c...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Minchom, Anna, Thavasu, Parames, Ahmad, Zai, Stewart, Adam, Georgiou, Alexandros, O’Brien, Mary E. R., Popat, Sanjay, Bhosle, Jaishree, Yap, Timothy A., de Bono, Johann, Banerji, Udai
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628934/
https://ncbi.nlm.nih.gov/pubmed/28982179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186106
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