Differences in signaling patterns on PI3K inhibition reveal context specificity in KRAS mutant cancers

It is increasingly appreciated that drug response to different cancers driven by the same oncogene is different and may relate to differences in re-wiring of signal transduction. We aimed to study differences in dynamic signaling changes within mutant KRAS (KRAS(MT)), non-small cell lung cancer (NSC...

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Bibliografski detalji
Izdano u:Mol Cancer Ther
Glavni autori: Stewart, Adam, Coker, Elizabeth A, Pölsterl, Sebastian, Georgiou, Alexandros, Minchom, Anna R, Carreira, Suzanne, Cunningham, David, O’Brien, Mary ER, Raynaud, Florence I, de Bono, Johann S, Al-Lazikani, Bissan, Banerji, Udai
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679718/
https://ncbi.nlm.nih.gov/pubmed/31262731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0727
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