Differences in signaling patterns on PI3K inhibition reveal context specificity in KRAS mutant cancers

It is increasingly appreciated that drug response to different cancers driven by the same oncogene is different and may relate to differences in re-wiring of signal transduction. We aimed to study differences in dynamic signaling changes within mutant KRAS (KRAS(MT)), non-small cell lung cancer (NSC...

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Bibliografiset tiedot
Julkaisussa:Mol Cancer Ther
Päätekijät: Stewart, Adam, Coker, Elizabeth A, Pölsterl, Sebastian, Georgiou, Alexandros, Minchom, Anna R, Carreira, Suzanne, Cunningham, David, O’Brien, Mary ER, Raynaud, Florence I, de Bono, Johann S, Al-Lazikani, Bissan, Banerji, Udai
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679718/
https://ncbi.nlm.nih.gov/pubmed/31262731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0727
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