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Inactivation of NF1 promotes resistance to EGFR inhibition in KRAS/NRAS/BRAF(V600)-wildtype colorectal cancer
Through the use of an unbiased, genome-scale CRISPR modifier screen, we identified NF1 suppression as a mechanism of resistance to EGFR inhibition in NRAS/KRAS/BRAF(V600)-wildtype colorectal cancer (CRC) cells. Reduced NF1 expression permitted sustained signalling through the MAPK (mitogen-activated...
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| Publicado no: | Mol Cancer Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7611272/ https://ncbi.nlm.nih.gov/pubmed/32098826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-1201 |
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