Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition

We have previously demonstrated an increased DNA copy number and expression of IGF1R to be associated with poor outcome in Wilms tumors. We have now tested whether inhibiting this receptor may be a useful therapeutic strategy by using a panel of Wilms tumor cell lines. Both genetic and pharmacologic...

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Detalhes bibliográficos
Main Authors: Bielen, Aleksandra, Box, Gary, Perryman, Lara, Bjerke, Lynn, Popov, Sergey, Jamin, Yann, Jury, Alexa, Valenti, Melanie, Brandon, Alexis de Haven, Martins, Vanessa, Romanet, Vincent, Jeay, Sebastien, Raynaud, Florence I., Hofmann, Francesco, Robinson, Simon P., Eccles, Suzanne A., Jones, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356645/
https://ncbi.nlm.nih.gov/pubmed/22529373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105034109
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