Enhanced efficacy of IGF1R inhibition in paediatric glioblastoma by combinatorial targeting of PDGFRα/β

Paediatric glioblastoma (pGBM), although rare, is one of the leading causes of cancer-related deaths in children, with tumours essentially refractory to existing treatments. We have identified IGF1R to be a potential therapeutic target in pGBM due to gene amplification and high levels of IGF2 expres...

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Hauptverfasser: Bielen, Aleksandra, Perryman, Lara, Box, Gary M., Valenti, Melanie, de Haven Brandon, Alexis, Martins, Vanessa, Jury, Alexa, Popov, Sergey, Gowan, Sharon, Jeay, Sebastien, Raynaud, Florence I., Hofmann, Francesco, Hargrave, Darren, Eccles, Suzanne A., Jones, Chris
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160488/
https://ncbi.nlm.nih.gov/pubmed/21659463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0205
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