Structure-based drug design: aiming for a perfect fit

Por van Montfort, Rob L.M., Workman, Paul
Publicado no Essays Biochem (2017)

Drugging the PI3 Kinome: From Chemical Tools to Drugs in the Clinic

Por Workman, Paul, Clarke, Paul A, Raynaud, Florence I, van Montfort, Rob LM
Publicado em 2010

Crystal structure of truncated human βB1-crystallin

Por van Montfort, Rob L.M., Bateman, Orval A., Lubsen, Nicolette H., Slingsby, Christine
Publicado em 2003

Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle...

Por Fearon, Daren, Westwood, Isaac M., van Montfort, Rob L.M., Bayliss, Richard, Jones, Keith, Bavetsias, Vassilios
Publicado no Bioorg Med Chem (2018)

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Por Westwood, Isaac, Cheary, Donna-Marie, Baxter, Joanne E., Richards, Mark W., van Montfort, Rob L.M., Fry, Andrew M., Bayliss, Richard
Publicado em 2009

Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography

Por Matijssen, Cornelis, Silva-Santisteban, M. Cris, Westwood, Isaac M., Siddique, Samerene, Choi, Vanessa, Sheldrake, Peter, van Montfort, Rob L.M., Blagg, Julian
Publicado em 2012

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

Por Couty, Sylvain, Westwood, Isaac M., Kalusa, Andrew, Cano, Celine, Travers, Jon, Boxall, Kathy, Chow, Chiau Ling, Burns, Sam, Schmitt, Jessica, Pickard, Lisa, Barillari, Caterina, McAndrew, P. Craig, Clarke, Paul A., Linardopoulos, Spiros, Griffin, Roger J., Aherne, G. Wynne, Raynaud, Florence I., Workman, Paul, Jones, Keith, van Montfort, Rob L.M.
Publicado em 2013

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (K...

Por Le Bihan, Yann-Vaï, Lanigan, Rachel M., Atrash, Butrus, McLaughlin, Mark G., Velupillai, Srikannathasan, Malcolm, Andrew G., England, Katherine S., Ruda, Gian Filippo, Mok, N. Yi, Tumber, Anthony, Tomlin, Kathy, Saville, Harry, Shehu, Erald, McAndrew, Craig, Carmichael, LeAnne, Bennett, James M., Jeganathan, Fiona, Eve, Paul, Donovan, Adam, Hayes, Angela, Wood, Francesca, Raynaud, Florence I., Fedorov, Oleg, Brennan, Paul E., Burke, Rosemary, van Montfort, Rob L.M., Rossanese, Olivia W., Blagg, Julian, Bavetsias, Vassilios
Publicado no Eur J Med Chem (2019)