Neuronal Lifespan versus Healthspan: Principles of Natural Selection at Work in the Degenerating Brain

Por O’Leary, John C., Koren, John, Dickey, Chad A.
Publicado no J Mol Neurosci (2011)

The role of FKBP5 in mood disorders: Action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance

Por O’Leary, John C., Zhang, Bo, Koren, John, Blair, Laura, Dickey, Chad A.
Publicado no CNS Neurol Disord Drug Targets (2013)

Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases

Por Jinwal, Umesh K., Koren, John, O’Leary, John C., Jones, Jeffrey R., Abisambra, Jose F., Dickey, Chad A.
Publicado em 2010

Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency

Por Sabbagh, Jonathan J., O'Leary, John C., Blair, Laura J., Klengel, Torsten, Nordhues, Bryce A., Fontaine, Sarah N., Binder, Elisabeth B., Dickey, Chad A.
Publicado em 2014

Cdc37/Hsp90 Protein Complex Disruption Triggers an Autophagic Clearance Cascade for TDP-43 Protein

Por Jinwal, Umesh K., Abisambra, Jose F., Zhang, Juan, Dharia, Sheetal, O'Leary, John C., Patel, Tina, Braswell, Kaitlyn, Jani, Twisha, Gestwicki, Jason E., Dickey, Chad A.
Publicado em 2012

Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance

Por Koren, John, Miyata, Yoshinari, Kiray, Janine, O'Leary, John C., Nguyen, Lana, Guo, Jianping, Blair, Laura J., Li, Xiokai, Jinwal, Umesh K., Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Publicado em 2012

Correction: Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance

Por Koren, John, Miyata, Yoshinari, Kiray, Janine, O'Leary, John C., Nguyen, Lana, Guo, Jianping, Blair, Laura J., Li, Xiaokai, Jinwal, Umesh K., Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Publicado em 2012

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

Por O'Leary, John C., Dharia, Sheetal, Blair, Laura J., Brady, Sarah, Johnson, Amelia G., Peters, Melinda, Cheung-Flynn, Joyce, Cox, Marc B., de Erausquin, Gabriel, Weeber, Edwin J., Jinwal, Umesh K., Dickey, Chad A.
Publicado em 2011

The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics

Por Jinwal, Umesh K., Trotter, Justin H., Abisambra, Jose F., Koren, John, Lawson, Lisa Y., Vestal, Grant D., O'Leary, John C., Johnson, Amelia G., Jin, Ying, Jones, Jeffrey R., Li, Qingyou, Weeber, Edwin J., Dickey, Chad A.
Publicado em 2011

The Diarylheptanoid (+)-aR,11S-Myricanol and Two Flavones from Bayberry (Myrica cerifera) Destabilize the Microtubule Associated Protein Tau

Por Jones, Jeffrey R., Lebar, Matthew D., Jinwal, Umesh K., Abisambra, Jose F., Koren, John, Blair, Laura, O'Leary, John C., Davey, Zachary, Trotter, Justin, Johnson, Amelia G., Weeber, Edwin, Eckman, Christopher B., Baker, Bill J., Dickey, Chad A.
Publicado em 2010

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

Por Jinwal, Umesh K., Koren, John, Borysov, Sergiy I., Schmid, Andreas B., Abisambra, Jose F., Blair, Laura J., Johnson, Amelia G., Jones, Jeffrey R., Shults, Cody L., O'Leary, John C., Jin, Ying, Buchner, Johannes, Cox, Marc B., Dickey, Chad A.
Publicado em 2010

Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

Por Suntharalingam, Amirthaa, Abisambra, Jose F., O'Leary, John C., Koren, John, Zhang, Bo, Joe, Myung Kuk, Blair, Laura J., Hill, Shannon E., Jinwal, Umesh K., Cockman, Matthew, Duerfeldt, Adam S., Tomarev, Stanislav, Blagg, Brian S. J., Lieberman, Raquel L., Dickey, Chad A.
Publicado em 2012

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

Por Abisambra, Jose F., Jinwal, Umesh K., Blair, Laura J., O'Leary, John C., Li, Qingyou, Brady, Sarah, Wang, Li, Guidi, Chantal E., Zhang, Bo, Nordhues, Bryce A., Cockman, Matthew, Suntharalingham, Amirthaa, Li, Pengfei, Jin, Ying, Atkins, Christopher A., Dickey, Chad A.
Publicado em 2013

Hsc70 Rapidly Engages Tau after Microtubule Destabilization

Por Jinwal, Umesh K., O'Leary, John C., Borysov, Sergiy I., Jones, Jeffrey R., Li, Qingyou, Koren, John, Abisambra, Jose F., Vestal, Grant D., Lawson, Lisa Y., Johnson, Amelia G., Blair, Laura J., Jin, Ying, Miyata, Yoshinari, Gestwicki, Jason E., Dickey, Chad A.
Publicado em 2010

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Por O'Leary, John C, Li, Qingyou, Marinec, Paul, Blair, Laura J, Congdon, Erin E, Johnson, Amelia G, Jinwal, Umesh K, Koren, John, Jones, Jeffrey R, Kraft, Clara, Peters, Melinda, Abisambra, Jose F, Duff, Karen E, Weeber, Edwin J, Gestwicki, Jason E, Dickey, Chad A
Publicado em 2010

Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice

Por Abisambra, Jose F., Blair, Laura J., Hill, Shannon E., Jones, Jeffrey R., Kraft, Clara, Rogers, Justin, Koren, John, Jinwal, Umesh K., Lawson, Lisa, Johnson, Amelia G., Wilcock, Donna, O'Leary, John C., Jansen-West, Karen, Muschol, Martin, Golde, Todd E., Weeber, Edwin J., Banko, Jessica, Dickey, Chad A.
Publicado em 2010

Imbalance of Hsp70 family variants fosters tau accumulation

Por Jinwal, Umesh K., Akoury, Elias, Abisambra, Jose F., O'Leary, John C., Thompson, Andrea D., Blair, Laura J., Jin, Ying, Bacon, Justin, Nordhues, Bryce A., Cockman, Matthew, Zhang, Juan, Li, Pengfei, Zhang, Bo, Borysov, Sergiy, Uversky, Vladimir N., Biernat, Jacek, Mandelkow, Eckhard, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Publicado em 2013

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Por Blair, Laura J., Nordhues, Bryce A., Hill, Shannon E., Scaglione, K. Matthew, O’Leary, John C., Fontaine, Sarah N., Breydo, Leonid, Zhang, Bo, Li, Pengfei, Wang, Li, Cotman, Carl, Paulson, Henry L., Muschol, Martin, Uversky, Vladimir N., Klengel, Torsten, Binder, Elisabeth B., Kayed, Rakez, Golde, Todd E., Berchtold, Nicole, Dickey, Chad A.
Publicado em 2013