Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance

MKT-077, a rhodacyanine dye, was shown to produce cancer specific cell death. However, complications prevented the use of this compound beyond clinical trials. Here we describe YM-1, a derivative of MKT-077. We found that YM-1 was more cytotoxic and localized differently than MKT-077. YM-1 demonstra...

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Detalhes bibliográficos
Main Authors: Koren, John, Miyata, Yoshinari, Kiray, Janine, O'Leary, John C., Nguyen, Lana, Guo, Jianping, Blair, Laura J., Li, Xiokai, Jinwal, Umesh K., Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338522/
https://ncbi.nlm.nih.gov/pubmed/22563386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035566
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