Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

Members of the 70-kDa heat shock family can control and manipulate a host of oncogenic client proteins. This role of Hsp70 in both the folding and degradation of these client proteins makes it a potential drug target for certain forms of cancer. The phenothiazine family of compounds, as well as the...

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Detalles Bibliográficos
Autores principales: Koren, John, Jinwal, Umesh K., Jin, Ying, O'Leary, John, Jones, Jeff R., Johnson, Amelia G., Blair, Laura J., Abisambra, Jose F., Chang, Lyra, Miyata, Yoshinari, Cheng, Anna M., Guo, Jianping, Cheng, Jin Q., Gestwicki, Jason E., Dickey, Chad A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807306/
https://ncbi.nlm.nih.gov/pubmed/19889640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057208
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