Hsc70 Rapidly Engages Tau after Microtubule Destabilization

The microtubule-associated protein Tau plays a crucial role in regulating the dynamic stability of microtubules during neuronal development and synaptic transmission. In a group of neurodegenerative diseases, such as Alzheimer disease and other tauopathies, conformational changes in Tau are associat...

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Main Authors: Jinwal, Umesh K., O'Leary, John C., Borysov, Sergiy I., Jones, Jeffrey R., Li, Qingyou, Koren, John, Abisambra, Jose F., Vestal, Grant D., Lawson, Lisa Y., Johnson, Amelia G., Blair, Laura J., Jin, Ying, Miyata, Yoshinari, Gestwicki, Jason E., Dickey, Chad A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878041/
https://ncbi.nlm.nih.gov/pubmed/20308058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113753
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