The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

The pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal microtubule (MT)-associated protein that functions to maintain MT stability, is implicated in a number of hereditary and sporadic neurodegenerative diseases including frontotemporal dementia and Alzheimer&...

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Bibliografiske detaljer
Udgivet i:Hum Mol Genet
Main Authors: Fontaine, Sarah N., Martin, Mackenzie D., Akoury, Elias, Assimon, Victoria A., Borysov, Sergiy, Nordhues, Bryce A., Sabbagh, Jonathan J., Cockman, Matt, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560066/
https://ncbi.nlm.nih.gov/pubmed/25882706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv135
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