The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

Por Fontaine, Sarah N., Martin, Mackenzie D., Akoury, Elias, Assimon, Victoria A., Borysov, Sergiy, Nordhues, Bryce A., Sabbagh, Jonathan J., Cockman, Matt, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Publicado no Hum Mol Genet (2015)

Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules

Por Martin, Mackenzie D., Baker, Jeremy D., Suntharalingam, Amirthaa, Nordhues, Bryce A., Shelton, Lindsey B., Zheng, Dali, Sabbagh, Jonathan J., Haystead, Timothy A.J., Gestwicki, Jason E., Dickey, Chad A.
Publicado no ACS Chem Biol (2016)

Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance

Por Martin, Mackenzie D., Calcul, Laurent, Smith, Courtney, Jinwal, Umesh K., Fontaine, Sarah N., Darling, April, Seeley, Kent, Wojtas, Lukasz, Narayan, Malathi, Gestwicki, Jason E., Smith, Garry R., Reitz, Allen B., Baker, Bill J., Dickey, Chad A.
Publicado no ACS Chem Biol (2015)

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

Por Fontaine, Sarah N, Zheng, Dali, Sabbagh, Jonathan J, Martin, Mackenzie D, Chaput, Dale, Darling, April, Trotter, Justin H, Stothert, Andrew R, Nordhues, Bryce A, Lussier, April, Baker, Jeremy, Shelton, Lindsey, Kahn, Mahnoor, Blair, Laura J, Stevens, Stanley M, Dickey, Chad A
Publicado no EMBO J (2016)

Human cyclophilin 40 unravels neurotoxic amyloids

Por Baker, Jeremy D., Shelton, Lindsey B., Zheng, Dali, Favretto, Filippo, Nordhues, Bryce A., Darling, April, Sullivan, Leia E., Sun, Zheying, Solanki, Parth K., Martin, Mackenzie D., Suntharalingam, Amirthaa, Sabbagh, Jonathan J., Becker, Stefan, Mandelkow, Eckhard, Uversky, Vladimir N., Zweckstetter, Markus, Dickey, Chad A., Koren, John, Blair, Laura J.
Publicado no PLoS Biol (2017)