Specific binding of tetratricopeptide repeat (TPR) proteins to heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90) is regulated by affinity and phosphorylation

by Assimon, Victoria A., Southworth, Daniel R., Gestwicki, Jason E.
Published in Biochemistry (2015)

Hsp70 Protein Complexes as Drug Targets

by Assimon, Victoria A., Gillies, Anne T., Rauch, Jennifer N., Gestwicki, Jason E.
Published 2013

Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity

by Assimon, Victoria A., Shao, Hao, Garneau-Tsodikova, Sylvie, Gestwicki, Jason E.
Published in Medchemcomm (2015)

A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions

by Rinaldi, Silvia, Assimon, Victoria A., Young, Zapporah T., Morra, Giulia, Shao, Hao, Taylor, Isabelle R., Gestwicki, Jason E., Colombo, Giorgio
Published in ACS Chem Biol (2018)

Protein Cross-linking Capillary Electrophoresis at Increased Throughput for a Range of Protein-Protein Interactions

by Ouimet, Claire M., Dawod, Mohamed, Grinias, James, Assimon, Victoria A., Lodge, Jean, Mapp, Anna K., Gestwicki, Jason E., Kennedy, Robert T.
Published in Analyst (2018)

The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain

by Connarn, Jamie N., Assimon, Victoria A., Reed, Rebecca A., Tse, Eric, Southworth, Daniel R., Zuiderweg, Erik R. P., Gestwicki, Jason E., Sun, Duxin
Published 2014

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

by Fontaine, Sarah N., Martin, Mackenzie D., Akoury, Elias, Assimon, Victoria A., Borysov, Sergiy, Nordhues, Bryce A., Sabbagh, Jonathan J., Cockman, Matt, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Published in Hum Mol Genet (2015)

The E3 Ubiquitin Ligase CHIP and the Molecular Chaperone Hsc70 Form a Dynamic, Tethered Complex

by Smith, Matthew C., Scaglione, K. Matthew, Assimon, Victoria A., Patury, Srikanth, Thompson, Andrea D., Dickey, Chad A., Southworth, Daniel R., Paulson, Henry L., Gestwicki, Jason E., Zuiderweg, Erik R.P.
Published 2013

High-throughput screen for inhibitors of protein–protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex

by Taylor, Isabelle R., Dunyak, Bryan M., Komiyama, Tomoko, Shao, Hao, Ran, Xu, Assimon, Victoria A., Kalyanaraman, Chakrapani, Rauch, Jennifer N., Jacobson, Matthew P., Zuiderweg, Erik R. P., Gestwicki, Jason E.
Published in J Biol Chem (2018)

Specificity for latent C-termini links the E3 ubiquitin ligase CHIP to caspases

by Ravalin, Matthew, Theofilas, Panagiotis, Basu, Koli, Opoku-Nsiah, Kwadwo A., Assimon, Victoria A., Medina-Cleghorn, Daniel, Chen, Yi-Fan, Bohn, Markus F., Arkin, Michelle, Grinberg, Lea T., Craik, Charles S., Gestwicki, Jason E.
Published in Nat Chem Biol (2019)

Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells

by Taylor, Isabelle R., Assimon, Victoria A., Kuo, Szu Yu, Rinaldi, Silvia, Li, Xiaokai, Young, Zapporah T., Morra, Giulia, Green, Keith, Nguyen, Daniel, Shao, Hao, Garneau-Tsodikova, Sylvie, Colombo, Giorgio, Gestwicki, Jason E.
Published in Chem Sci (2020)

Predicting protein targets for drug-like compounds using transcriptomics

by Pabon, Nicolas A., Xia, Yan, Estabrooks, Samuel K., Ye, Zhaofeng, Herbrand, Amanda K., Süß, Evelyn, Biondi, Ricardo M., Assimon, Victoria A., Gestwicki, Jason E., Brodsky, Jeffrey L., Camacho, Carlos J., Bar-Joseph, Ziv
Published in PLoS Comput Biol (2018)

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy

by Young, Zapporah T., Rauch, Jennifer N., Assimon, Victoria A., Jinwal, Umesh, Ahn, Misol, Li, Xiaokai, Dunyak, Bryan M., Ahmad, Atta, Carlson, George, Srinivasan, Sharan R., Zuiderweg, Erik R. P., Dickey, Chad A., Gestwicki, Jason E.
Published in Cell Chem Biol (2016)

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

by Fontaine, Sarah N., Rauch, Jennifer N., Nordhues, Bryce A., Assimon, Victoria A., Stothert, Andrew R., Jinwal, Umesh K., Sabbagh, Jonathan J., Chang, Lyra, Stevens, Stanley M., Zuiderweg, Erik R. P., Gestwicki, Jason E., Dickey, Chad A.
Published in J Biol Chem (2015)

Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

by Mok, Sue-Ann, Condello, Carlo, Freilich, Rebecca, Gillies, Anne, Arhar, Taylor, Oroz, Javier, Kadavath, Harindranath, Julien, Olivier, Assimon, Victoria A., Rauch, Jennifer N., Dunyak, Bryan M., Lee, Jungsoon, Tsai, Francis T.F., Wilson, Mark R., Zweckstetter, Markus, Dickey, Chad A., Gestwicki, Jason E.
Published in Nat Struct Mol Biol (2018)