The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost

Por Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no Front Neurosci (2016)

Alzheimer’s disease biomarkers in animal models: closing the translational gap

Por Sabbagh, Jonathan J, Kinney, Jefferson W, Cummings, Jeffrey L
Publicado em 2013

Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease

Por Blair, Laura J., Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no Expert Opin Ther Targets (2014)

The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing and Alzheimer's disease

Por Blair, Laura J., Baker, Jeremy D., Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no J Neurochem (2015)

Targeting the ER-Autophagy System in the Trabecular Meshwork to Treat Glaucoma

Por Stothert, Andrew R., Fontaine, Sarah N., Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no Exp Eye Res (2015)

Chronic ketamine produces altered distribution of parvalbumin-positive cells in the hippocampus of adult rats

Por Sabbagh, Jonathan J., Murtishaw, Andrew S., Bolton, Monica M., Heaney, Chelcie F., Langhardt, Michael, Kinney, Jefferson W.
Publicado em 2013

MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation

Por Zheng, Dali, Sabbagh, Jonathan J., Blair, Laura J., Darling, April L., Wen, Xiaoqi, Dickey, Chad A.
Publicado no J Biol Chem (2016)

Baclofen administration alters fear extinction and GABAergic protein levels

Por Heaney, Chelcie F., Bolton, Monica M., Murtishaw, Andrew S., Sabbagh, Jonathan J., Magcalas, Christy M., Kinney, Jefferson W.
Publicado em 2012

Deficits in emotional learning and memory in an animal model of schizophrenia

Por Bolton, Monica M., Heaney, Chelcie F., Sabbagh, Jonathan J., Murtishaw, Andrew S., Magcalas, Christy M., Kinney, Jefferson W.
Publicado em 2012

Cellular factors modulating the mechanism of tau protein aggregation

Por Fontaine, Sarah N., Sabbagh, Jonathan J., Baker, Jeremy, Martinez-Licha, Carlos R., Darling, April, Dickey, Chad A.
Publicado no Cell Mol Life Sci (2015)

Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency

Por Sabbagh, Jonathan J., O'Leary, John C., Blair, Laura J., Klengel, Torsten, Nordhues, Bryce A., Fontaine, Sarah N., Binder, Elisabeth B., Dickey, Chad A.
Publicado em 2014

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

Por Fontaine, Sarah N., Martin, Mackenzie D., Akoury, Elias, Assimon, Victoria A., Borysov, Sergiy, Nordhues, Bryce A., Sabbagh, Jonathan J., Cockman, Matt, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Publicado no Hum Mol Genet (2015)

Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes

Por Sabbagh, Jonathan J., Fontaine, Sarah N., Shelton, Lindsey B., Blair, Laura J., Hunt, Jerry B., Zhang, Bo, Gutmann, Joseph M., Lee, Daniel C., Lloyd, John D., Dickey, Chad A.
Publicado no J Neurotrauma (2016)

Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules

Por Martin, Mackenzie D., Baker, Jeremy D., Suntharalingam, Amirthaa, Nordhues, Bryce A., Shelton, Lindsey B., Zheng, Dali, Sabbagh, Jonathan J., Haystead, Timothy A.J., Gestwicki, Jason E., Dickey, Chad A.
Publicado no ACS Chem Biol (2016)

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

Por Blair, Laura J, Frauen, Haley D, Zhang, Bo, Nordhues, Bryce A, Bijan, Sara, Lin, Yen-Chi, Zamudio, Frank, Hernandez, Lidice D, Sabbagh, Jonathan J, Selenica, Maj-Linda B, Dickey, Chad A
Publicado no Acta Neuropathol Commun (2015)

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

Por Fontaine, Sarah N., Rauch, Jennifer N., Nordhues, Bryce A., Assimon, Victoria A., Stothert, Andrew R., Jinwal, Umesh K., Sabbagh, Jonathan J., Chang, Lyra, Stevens, Stanley M., Zuiderweg, Erik R. P., Gestwicki, Jason E., Dickey, Chad A.
Publicado no J Biol Chem (2015)

Hsp90 activator Aha1 drives production of pathological tau aggregates

Por Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Sullivan, Leia E., Solanki, Parth K., Webster, Jack M., Sun, Zheying, Sabbagh, Jonathan J., Nordhues, Bryce A., Koren, John, Ghosh, Suman, Blagg, Brian S. J., Blair, Laura J., Dickey, Chad A.
Publicado no Proc Natl Acad Sci U S A (2017)

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

Por Fontaine, Sarah N, Zheng, Dali, Sabbagh, Jonathan J, Martin, Mackenzie D, Chaput, Dale, Darling, April, Trotter, Justin H, Stothert, Andrew R, Nordhues, Bryce A, Lussier, April, Baker, Jeremy, Shelton, Lindsey, Kahn, Mahnoor, Blair, Laura J, Stevens, Stanley M, Dickey, Chad A
Publicado no EMBO J (2016)

Human cyclophilin 40 unravels neurotoxic amyloids

Por Baker, Jeremy D., Shelton, Lindsey B., Zheng, Dali, Favretto, Filippo, Nordhues, Bryce A., Darling, April, Sullivan, Leia E., Sun, Zheying, Solanki, Parth K., Martin, Mackenzie D., Suntharalingam, Amirthaa, Sabbagh, Jonathan J., Becker, Stefan, Mandelkow, Eckhard, Uversky, Vladimir N., Zweckstetter, Markus, Dickey, Chad A., Koren, John, Blair, Laura J.
Publicado no PLoS Biol (2017)