Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

INTRODUCTION: The blood-brain barrier (BBB) is damaged in tauopathies, including progressive supranuclear palsy (PSP) and Alzheimer’s disease (AD), which is thought to contribute to pathogenesis later in the disease course. In AD, BBB dysfunction has been associated with amyloid beta (Aß) pathology,...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Blair, Laura J, Frauen, Haley D, Zhang, Bo, Nordhues, Bryce A, Bijan, Sara, Lin, Yen-Chi, Zamudio, Frank, Hernandez, Lidice D, Sabbagh, Jonathan J, Selenica, Maj-Linda B, Dickey, Chad A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353464/
https://ncbi.nlm.nih.gov/pubmed/25775028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0186-2
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