Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

INTRODUCTION: The blood-brain barrier (BBB) is damaged in tauopathies, including progressive supranuclear palsy (PSP) and Alzheimer’s disease (AD), which is thought to contribute to pathogenesis later in the disease course. In AD, BBB dysfunction has been associated with amyloid beta (Aß) pathology,...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Blair, Laura J, Frauen, Haley D, Zhang, Bo, Nordhues, Bryce A, Bijan, Sara, Lin, Yen-Chi, Zamudio, Frank, Hernandez, Lidice D, Sabbagh, Jonathan J, Selenica, Maj-Linda B, Dickey, Chad A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353464/
https://ncbi.nlm.nih.gov/pubmed/25775028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0186-2
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