Hsp90 activator Aha1 drives production of pathological tau aggregates

The microtubule-associated protein tau (MAPT, tau) forms neurotoxic aggregates that promote cognitive deficits in tauopathies, the most common of which is Alzheimer’s disease (AD). The 90-kDa heat shock protein (Hsp90) chaperone system affects the accumulation of these toxic tau species, which can b...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Sullivan, Leia E., Solanki, Parth K., Webster, Jack M., Sun, Zheying, Sabbagh, Jonathan J., Nordhues, Bryce A., Koren, John, Ghosh, Suman, Blagg, Brian S. J., Blair, Laura J., Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594679/
https://ncbi.nlm.nih.gov/pubmed/28827321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707039114
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