Hsp90 activator Aha1 drives production of pathological tau aggregates

The microtubule-associated protein tau (MAPT, tau) forms neurotoxic aggregates that promote cognitive deficits in tauopathies, the most common of which is Alzheimer’s disease (AD). The 90-kDa heat shock protein (Hsp90) chaperone system affects the accumulation of these toxic tau species, which can b...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Sullivan, Leia E., Solanki, Parth K., Webster, Jack M., Sun, Zheying, Sabbagh, Jonathan J., Nordhues, Bryce A., Koren, John, Ghosh, Suman, Blagg, Brian S. J., Blair, Laura J., Dickey, Chad A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594679/
https://ncbi.nlm.nih.gov/pubmed/28827321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707039114
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