Targeting the ER-Autophagy System in the Trabecular Meshwork to Treat Glaucoma

Por Stothert, Andrew R., Fontaine, Sarah N., Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no Exp Eye Res (2015)

Nuclear localization of clathrin involves a labile helix outside the trimerization domain

Por Ybe, Joel A., Fontaine, Sarah N., Stone, Todd, Nix, Jay, Lin, Xiaoyan, Mishra, Sanjay
Publicado em 2012

Cellular factors modulating the mechanism of tau protein aggregation

Por Fontaine, Sarah N., Sabbagh, Jonathan J., Baker, Jeremy, Martinez-Licha, Carlos R., Darling, April, Dickey, Chad A.
Publicado no Cell Mol Life Sci (2015)

Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency

Por Sabbagh, Jonathan J., O'Leary, John C., Blair, Laura J., Klengel, Torsten, Nordhues, Bryce A., Fontaine, Sarah N., Binder, Elisabeth B., Dickey, Chad A.
Publicado em 2014

Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma

Por Stothert, Andrew R., Suntharalingam, Amirthaa, Huard, Dustin J. E., Fontaine, Sarah N., Crowley, Vincent M., Mishra, Sanket, Blagg, Brian S. J., Lieberman, Raquel L., Dickey, Chad A.
Publicado no Hum Mol Genet (2014)

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics

Por Fontaine, Sarah N., Martin, Mackenzie D., Akoury, Elias, Assimon, Victoria A., Borysov, Sergiy, Nordhues, Bryce A., Sabbagh, Jonathan J., Cockman, Matt, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Publicado no Hum Mol Genet (2015)

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

Por Meier, Shelby, Bell, Michelle, Lyons, Danielle N., Rodriguez-Rivera, Jennifer, Ingram, Alexandria, Fontaine, Sarah N., Mechas, Elizabeth, Chen, Jing, Wolozin, Benjamin, LeVine, Harry, Zhu, Haining, Abisambra, Jose F.
Publicado no J Neurosci (2016)

Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes

Por Sabbagh, Jonathan J., Fontaine, Sarah N., Shelton, Lindsey B., Blair, Laura J., Hunt, Jerry B., Zhang, Bo, Gutmann, Joseph M., Lee, Daniel C., Lloyd, John D., Dickey, Chad A.
Publicado no J Neurotrauma (2016)

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

Por Fontaine, Sarah N., Rauch, Jennifer N., Nordhues, Bryce A., Assimon, Victoria A., Stothert, Andrew R., Jinwal, Umesh K., Sabbagh, Jonathan J., Chang, Lyra, Stevens, Stanley M., Zuiderweg, Erik R. P., Gestwicki, Jason E., Dickey, Chad A.
Publicado no J Biol Chem (2015)

Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance

Por Martin, Mackenzie D., Calcul, Laurent, Smith, Courtney, Jinwal, Umesh K., Fontaine, Sarah N., Darling, April, Seeley, Kent, Wojtas, Lukasz, Narayan, Malathi, Gestwicki, Jason E., Smith, Garry R., Reitz, Allen B., Baker, Bill J., Dickey, Chad A.
Publicado no ACS Chem Biol (2015)

Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach

Por Fontaine, Sarah N., Ingram, Alexandria, Cloyd, Ryan A., Meier, Shelby E., Miller, Emily, Lyons, Danielle, Nation, Grant K., Mechas, Elizabeth, Weiss, Blaine, Lanzillotta, Chiara, Di Domenico, Fabio, Schmitt, Frederick, Powell, David K., Vandsburger, Moriel, Abisambra, Jose F.
Publicado no Neurobiol Aging (2017)

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

Por Fontaine, Sarah N, Zheng, Dali, Sabbagh, Jonathan J, Martin, Mackenzie D, Chaput, Dale, Darling, April, Trotter, Justin H, Stothert, Andrew R, Nordhues, Bryce A, Lussier, April, Baker, Jeremy, Shelton, Lindsey, Kahn, Mahnoor, Blair, Laura J, Stevens, Stanley M, Dickey, Chad A
Publicado no EMBO J (2016)

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Por Blair, Laura J., Nordhues, Bryce A., Hill, Shannon E., Scaglione, K. Matthew, O’Leary, John C., Fontaine, Sarah N., Breydo, Leonid, Zhang, Bo, Li, Pengfei, Wang, Li, Cotman, Carl, Paulson, Henry L., Muschol, Martin, Uversky, Vladimir N., Klengel, Torsten, Binder, Elisabeth B., Kayed, Rakez, Golde, Todd E., Berchtold, Nicole, Dickey, Chad A.
Publicado em 2013