Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance

We previously discovered that one specific scalemic preparation of myricanol (1), a constituent of Myrica cerifera (bayberry/southern wax myrtle) root bark, could lower the levels of the microtubule-associated protein tau (MAPT). The significance is that tau accumulates in a number of neurodegenerat...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Martin, Mackenzie D., Calcul, Laurent, Smith, Courtney, Jinwal, Umesh K., Fontaine, Sarah N., Darling, April, Seeley, Kent, Wojtas, Lukasz, Narayan, Malathi, Gestwicki, Jason E., Smith, Garry R., Reitz, Allen B., Baker, Bill J., Dickey, Chad A.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971885/
https://ncbi.nlm.nih.gov/pubmed/25588114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb501013w
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