Imbalance of Hsp70 family variants fosters tau accumulation

Dysfunctional tau accumulation is a major contributing factor in tauopathies, and the heat-shock protein 70 (Hsp70) seems to play an important role in this accumulation. Several reports suggest that Hsp70 proteins can cause tau degradation to be accelerated or slowed, but how these opposing activiti...

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Hauptverfasser: Jinwal, Umesh K., Akoury, Elias, Abisambra, Jose F., O'Leary, John C., Thompson, Andrea D., Blair, Laura J., Jin, Ying, Bacon, Justin, Nordhues, Bryce A., Cockman, Matthew, Zhang, Juan, Li, Pengfei, Zhang, Bo, Borysov, Sergiy, Uversky, Vladimir N., Biernat, Jacek, Mandelkow, Eckhard, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2013
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606536/
https://ncbi.nlm.nih.gov/pubmed/23271055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-220889
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