Imbalance of Hsp70 family variants fosters tau accumulation

Dysfunctional tau accumulation is a major contributing factor in tauopathies, and the heat-shock protein 70 (Hsp70) seems to play an important role in this accumulation. Several reports suggest that Hsp70 proteins can cause tau degradation to be accelerated or slowed, but how these opposing activiti...

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Autores principales: Jinwal, Umesh K., Akoury, Elias, Abisambra, Jose F., O'Leary, John C., Thompson, Andrea D., Blair, Laura J., Jin, Ying, Bacon, Justin, Nordhues, Bryce A., Cockman, Matthew, Zhang, Juan, Li, Pengfei, Zhang, Bo, Borysov, Sergiy, Uversky, Vladimir N., Biernat, Jacek, Mandelkow, Eckhard, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2013
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606536/
https://ncbi.nlm.nih.gov/pubmed/23271055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-220889
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