Imbalance of Hsp70 family variants fosters tau accumulation

Dysfunctional tau accumulation is a major contributing factor in tauopathies, and the heat-shock protein 70 (Hsp70) seems to play an important role in this accumulation. Several reports suggest that Hsp70 proteins can cause tau degradation to be accelerated or slowed, but how these opposing activiti...

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主要な著者: Jinwal, Umesh K., Akoury, Elias, Abisambra, Jose F., O'Leary, John C., Thompson, Andrea D., Blair, Laura J., Jin, Ying, Bacon, Justin, Nordhues, Bryce A., Cockman, Matthew, Zhang, Juan, Li, Pengfei, Zhang, Bo, Borysov, Sergiy, Uversky, Vladimir N., Biernat, Jacek, Mandelkow, Eckhard, Gestwicki, Jason E., Zweckstetter, Markus, Dickey, Chad A.
フォーマット: Artigo
言語:Inglês
出版事項: Federation of American Societies for Experimental Biology 2013
主題:
Research Communications
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606536/
https://ncbi.nlm.nih.gov/pubmed/23271055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-220889
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