Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy

Heat shock protein 70 (Hsp70) is a chaperone that normally scans the proteome and initiates the turnover of some proteins (termed “clients”) by linking them to the degradation pathways. This activity is critical to normal protein homeostasis, yet it appears to fail in diseases associated with abnorm...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Chem Biol
Hlavní autoři: Young, Zapporah T., Rauch, Jennifer N., Assimon, Victoria A., Jinwal, Umesh, Ahn, Misol, Li, Xiaokai, Dunyak, Bryan M., Ahmad, Atta, Carlson, George, Srinivasan, Sharan R., Zuiderweg, Erik R. P., Dickey, Chad A., Gestwicki, Jason E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992411/
https://ncbi.nlm.nih.gov/pubmed/27499529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.04.014
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky