Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy

Heat shock protein 70 (Hsp70) is a chaperone that normally scans the proteome and initiates the turnover of some proteins (termed “clients”) by linking them to the degradation pathways. This activity is critical to normal protein homeostasis, yet it appears to fail in diseases associated with abnorm...

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Publicado en:Cell Chem Biol
Main Authors: Young, Zapporah T., Rauch, Jennifer N., Assimon, Victoria A., Jinwal, Umesh, Ahn, Misol, Li, Xiaokai, Dunyak, Bryan M., Ahmad, Atta, Carlson, George, Srinivasan, Sharan R., Zuiderweg, Erik R. P., Dickey, Chad A., Gestwicki, Jason E.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992411/
https://ncbi.nlm.nih.gov/pubmed/27499529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.04.014
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