Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy

Heat shock protein 70 (Hsp70) is a chaperone that normally scans the proteome and initiates the turnover of some proteins (termed “clients”) by linking them to the degradation pathways. This activity is critical to normal protein homeostasis, yet it appears to fail in diseases associated with abnorm...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Young, Zapporah T., Rauch, Jennifer N., Assimon, Victoria A., Jinwal, Umesh, Ahn, Misol, Li, Xiaokai, Dunyak, Bryan M., Ahmad, Atta, Carlson, George, Srinivasan, Sharan R., Zuiderweg, Erik R. P., Dickey, Chad A., Gestwicki, Jason E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992411/
https://ncbi.nlm.nih.gov/pubmed/27499529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.04.014
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados