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Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents

[Image: see text] The rhodacyanine, MKT-077, has antiproliferative activity against cancer cell lines through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. However, MKT-077 is rapidly metabolized, which limits its use as either a chemical probe o...

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Detalles Bibliográficos
Main Authors: Li, Xiaokai, Srinivasan, Sharan R., Connarn, Jamie, Ahmad, Atta, Young, Zapporah T., Kabza, Adam M., Zuiderweg, Erik. R. P., Sun, Duxin, Gestwicki, Jason E.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845967/
https://ncbi.nlm.nih.gov/pubmed/24312699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400204n
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