The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

Imbalanced protein load within cells is a critical aspect for most diseases of aging. In particular, the accumulation of proteins into neurotoxic aggregates is a common thread for a host of neurodegenerative diseases. Our previous work demonstrated that age-related changes to the cellular chaperone...

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Autores principales: Jinwal, Umesh K., Koren, John, Borysov, Sergiy I., Schmid, Andreas B., Abisambra, Jose F., Blair, Laura J., Johnson, Amelia G., Jones, Jeffrey R., Shults, Cody L., O'Leary, John C., Jin, Ying, Buchner, Johannes, Cox, Marc B., Dickey, Chad A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830818/
https://ncbi.nlm.nih.gov/pubmed/20071522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4815-09.2010
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