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The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

Imbalanced protein load within cells is a critical aspect for most diseases of aging. In particular, the accumulation of proteins into neurotoxic aggregates is a common thread for a host of neurodegenerative diseases. Our previous work demonstrated that age-related changes to the cellular chaperone...

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Détails bibliographiques
Auteurs principaux: Jinwal, Umesh K., Koren, John, Borysov, Sergiy I., Schmid, Andreas B., Abisambra, Jose F., Blair, Laura J., Johnson, Amelia G., Jones, Jeffrey R., Shults, Cody L., O'Leary, John C., Jin, Ying, Buchner, Johannes, Cox, Marc B., Dickey, Chad A.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830818/
https://ncbi.nlm.nih.gov/pubmed/20071522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4815-09.2010
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