A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

The gene FKBP5 codes for FKBP51, a co-chaperone protein of the Hsp90 complex that increases with age. Through its association with Hsp90, FKBP51 regulates the glucocorticoid receptor (GR). Single nucleotide polymorphisms (SNPs) in the FKBP5 gene associate with increased recurrence of depressive epis...

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Detalhes bibliográficos
Main Authors: O'Leary, John C., Dharia, Sheetal, Blair, Laura J., Brady, Sarah, Johnson, Amelia G., Peters, Melinda, Cheung-Flynn, Joyce, Cox, Marc B., de Erausquin, Gabriel, Weeber, Edwin J., Jinwal, Umesh K., Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174203/
https://ncbi.nlm.nih.gov/pubmed/21935478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024840
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