A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

The gene FKBP5 codes for FKBP51, a co-chaperone protein of the Hsp90 complex that increases with age. Through its association with Hsp90, FKBP51 regulates the glucocorticoid receptor (GR). Single nucleotide polymorphisms (SNPs) in the FKBP5 gene associate with increased recurrence of depressive epis...

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Библиографические подробности
Главные авторы: O'Leary, John C., Dharia, Sheetal, Blair, Laura J., Brady, Sarah, Johnson, Amelia G., Peters, Melinda, Cheung-Flynn, Joyce, Cox, Marc B., de Erausquin, Gabriel, Weeber, Edwin J., Jinwal, Umesh K., Dickey, Chad A.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174203/
https://ncbi.nlm.nih.gov/pubmed/21935478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024840
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