Cdc37/Hsp90 Protein Complex Disruption Triggers an Autophagic Clearance Cascade for TDP-43 Protein

The RNA-binding protein, trans-active response DNA-binding protein 43 (TDP-43), is normally found in the nucleus, but in amyotrophic lateral sclerosis, frontal temporal dementia, and some cases of Alzheimer disease it is cleaved and mislocalized to the cytosol, leading to accumulation. The mechanism...

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Détails bibliographiques
Auteurs principaux: Jinwal, Umesh K., Abisambra, Jose F., Zhang, Juan, Dharia, Sheetal, O'Leary, John C., Patel, Tina, Braswell, Kaitlyn, Jani, Twisha, Gestwicki, Jason E., Dickey, Chad A.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397908/
https://ncbi.nlm.nih.gov/pubmed/22674575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.367268
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