The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics

The microtubule-associated protein tau, which becomes hyperphosphorylated and pathologically aggregates in a number of these diseases, is extremely sensitive to manipulations of chaperone signaling. For example, Hsp90 inhibitors can reduce the levels of tau in transgenic mouse models of tauopathy. B...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jinwal, Umesh K., Trotter, Justin H., Abisambra, Jose F., Koren, John, Lawson, Lisa Y., Vestal, Grant D., O'Leary, John C., Johnson, Amelia G., Jin, Ying, Jones, Jeffrey R., Li, Qingyou, Weeber, Edwin J., Dickey, Chad A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089541/
https://ncbi.nlm.nih.gov/pubmed/21367866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182493
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