The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics

The microtubule-associated protein tau, which becomes hyperphosphorylated and pathologically aggregates in a number of these diseases, is extremely sensitive to manipulations of chaperone signaling. For example, Hsp90 inhibitors can reduce the levels of tau in transgenic mouse models of tauopathy. B...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Jinwal, Umesh K., Trotter, Justin H., Abisambra, Jose F., Koren, John, Lawson, Lisa Y., Vestal, Grant D., O'Leary, John C., Johnson, Amelia G., Jin, Ying, Jones, Jeffrey R., Li, Qingyou, Weeber, Edwin J., Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089541/
https://ncbi.nlm.nih.gov/pubmed/21367866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182493
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados