Cdc37/Hsp90 Protein Complex Disruption Triggers an Autophagic Clearance Cascade for TDP-43 Protein

The RNA-binding protein, trans-active response DNA-binding protein 43 (TDP-43), is normally found in the nucleus, but in amyotrophic lateral sclerosis, frontal temporal dementia, and some cases of Alzheimer disease it is cleaved and mislocalized to the cytosol, leading to accumulation. The mechanism...

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Detalhes bibliográficos
Main Authors: Jinwal, Umesh K., Abisambra, Jose F., Zhang, Juan, Dharia, Sheetal, O'Leary, John C., Patel, Tina, Braswell, Kaitlyn, Jani, Twisha, Gestwicki, Jason E., Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397908/
https://ncbi.nlm.nih.gov/pubmed/22674575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.367268
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