CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration

OBJECTIVE: Kinase hyperactivity occurs in both neurodegenerative disease and cancer. Lesions containing hyperphosphorylated aggregated TDP-43 characterize amyotrophic lateral sclerosis and frontotemporal lobar degeneration with TDP-43 inclusions. Dual phosphorylation of TDP-43 at serines 409/410 dri...

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Detaylı Bibliyografya
Asıl Yazarlar: Liachko, Nicole F., McMillan, Pamela J., Guthrie, Chris R., Bird, Thomas D., Leverenz, James B., Kraemer, Brian C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775949/
https://ncbi.nlm.nih.gov/pubmed/23424178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23870
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