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CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration
OBJECTIVE: Kinase hyperactivity occurs in both neurodegenerative disease and cancer. Lesions containing hyperphosphorylated aggregated TDP-43 characterize amyotrophic lateral sclerosis and frontotemporal lobar degeneration with TDP-43 inclusions. Dual phosphorylation of TDP-43 at serines 409/410 dri...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3775949/ https://ncbi.nlm.nih.gov/pubmed/23424178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23870 |
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