Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). However, the cellular and genetic mechanisms at work in pathological TDP-43 toxicity are not fully elucidated. To identify ge...

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Udgivet i:PLoS Genet
Main Authors: Liachko, Nicole F., Saxton, Aleen D., McMillan, Pamela J., Strovas, Timothy J., Keene, C. Dirk, Bird, Thomas D., Kraemer, Brian C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934317/
https://ncbi.nlm.nih.gov/pubmed/31834878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008526
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