The phosphatase calcineurin regulates pathological TDP-43 phosphorylation

Detergent insoluble inclusions of TDP-43 protein are hallmarks of the neuropathology in over 90% of amyotrophic lateral sclerosis (ALS) cases and approximately half of frontotemporal dementia (FTLD-TDP) cases. In TDP-43 proteinopathy disorders, lesions containing aggregated TDP-43 protein are extens...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: Liachko, Nicole F., Saxton, Aleen D., McMillan, Pamela J., Strovas, Timothy J., Currey, Heather N., Taylor, Laura M., Wheeler, Jeanna M., Oblak, Adrian L., Ghetti, Bernardino, Montine, Thomas J., Keene, C. Dirk, Raskind, Murray A., Bird, Thomas D., Kraemer, Brian C.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026939/
https://ncbi.nlm.nih.gov/pubmed/27473149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1600-y
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