The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

Pathological aggregates of phosphorylated TDP-43 characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), two devastating groups of neurodegenerative disease. Kinase hyperactivity may be a consistent feature of ALS and FTLD-TDP, as phosphorylated TDP-43 is n...

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Vydáno v:PLoS Genet
Hlavní autoři: Liachko, Nicole F., McMillan, Pamela J., Strovas, Timothy J., Loomis, Elaine, Greenup, Lynne, Murrell, Jill R., Ghetti, Bernardino, Raskind, Murray A., Montine, Thomas J., Bird, Thomas D., Leverenz, James B., Kraemer, Brian C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256087/
https://ncbi.nlm.nih.gov/pubmed/25473830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004803
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