Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

BACKGROUND: Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein deposits, typically containing either aberrantly phosphorylated TDP-43 or tau. Our...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Taylor, Laura M., McMillan, Pamela J., Liachko, Nicole F., Strovas, Timothy J., Ghetti, Bernardino, Bird, Thomas D., Keene, C. Dirk, Kraemer, Brian C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802059/
https://ncbi.nlm.nih.gov/pubmed/29409526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0237-9
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