Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice

The kinase TTBK1 is predominantly expressed in the central nervous system and has been implicated in neurodegenerative diseases including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis through its ability to phosphorylate the proteins tau and TDP-43. Mutati...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: McMillan, Pamela, Wheeler, Jeanna, Gatlin, Rachel E., Taylor, Laura, Strovas, Tim, Baum, Misa, Bird, Thomas D., Latimer, Caitlin, Keene, C. Dirk, Kraemer, Brian C., Liachko, Nicole F.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7684928/
https://ncbi.nlm.nih.gov/pubmed/33228809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01073-7
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