Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice

The kinase TTBK1 is predominantly expressed in the central nervous system and has been implicated in neurodegenerative diseases including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis through its ability to phosphorylate the proteins tau and TDP-43. Mutati...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: McMillan, Pamela, Wheeler, Jeanna, Gatlin, Rachel E., Taylor, Laura, Strovas, Tim, Baum, Misa, Bird, Thomas D., Latimer, Caitlin, Keene, C. Dirk, Kraemer, Brian C., Liachko, Nicole F.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7684928/
https://ncbi.nlm.nih.gov/pubmed/33228809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01073-7
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