From model system to clinical medicine: pathophysiologic links of common proteinopathies

por McMillan, Pamela J, Leverenz, James B
Publicado 2010

Tau tubulin kinases in proteinopathy

por Taylor, Laura M., McMillan, Pamela J., Kraemer, Brian C., Liachko, Nicole F.
Publicado en FEBS J (2019)

Truncation of tau at E391 Promotes Early Pathological Changes in Transgenic Mice

por McMillan, Pamela J., Kraemer, Brian C., Robinson, Linda, Leverenz, James B., Raskind, Murray, Schellenberg, Gerard
Publicado 2011

Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease

por McMillan, Pamela J, White, Sylvia S, Franklin, Allyn, Greenup, J Lynne, Leverenz, James B, Raskind, Murray A, Szot, Patricia
Publicado 2010

CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration

por Liachko, Nicole F., McMillan, Pamela J., Guthrie, Chris R., Bird, Thomas D., Leverenz, James B., Kraemer, Brian C.
Publicado 2013

Tau isoform regulation is region and cell-specific in mouse brain

por McMillan, Pamela, Korvatska, Elena, Poorkaj, Parvoneh, Evstafjeva, Zana, Robinson, Linda, Greenup, Lynne, Leverenz, James, Schellenberg, Gerard D., D’Souza, Ian
Publicado 2008

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

por Liachko, Nicole F., Saxton, Aleen D., McMillan, Pamela J., Strovas, Timothy J., Keene, C. Dirk, Bird, Thomas D., Kraemer, Brian C.
Publicado en PLoS Genet (2019)

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

por Taylor, Laura M., McMillan, Pamela J., Liachko, Nicole F., Strovas, Timothy J., Ghetti, Bernardino, Bird, Thomas D., Keene, C. Dirk, Kraemer, Brian C.
Publicado en Mol Neurodegener (2018)

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.

por Kow, Rebecca L., Strovas, Timothy J., McMillan, Pamela J., Jacobi, Ashley M., Behlke, Mark A., Saxton, Aleen D., Latimer, Caitlin S., Keene, C. Dirk, Kraemer, Brian C.
Publicado en Neurobiol Dis (2020)

Proteomic Identification of Novel Proteins in Cortical Lewy Bodies

por Leverenz, James B., Umar, Imran, Wang, Qing, Montine, Thomas J., McMillan, Pamela J., Tsuang, Debby W., Jin, Jinghua, Pan, Catherine, Shin, Jenny, Zhu, David, Zhang, Jing
Publicado en Brain Pathol (2007)

Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer’s Disease Is Associated with the Apolipoprotein E-ε4 Allele

por Cook, David G., Leverenz, James B., McMillan, Pamela J., Kulstad, J. Jacob, Ericksen, Sasha, Roth, Richard A., Schellenberg, Gerard D., Jin, Lee-Way, Kovacina, Kristina S., Craft, Suzanne
Publicado 2003

Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice

por McMillan, Pamela, Wheeler, Jeanna, Gatlin, Rachel E., Taylor, Laura, Strovas, Tim, Baum, Misa, Bird, Thomas D., Latimer, Caitlin, Keene, C. Dirk, Kraemer, Brian C., Liachko, Nicole F.
Publicado en Acta Neuropathol Commun (2020)

Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

por McMillan, Pamela J., Strovas, Timothy J., Baum, Misa, Mitchell, Brooke K., Eck, Randall J., Hendricks, Nzinga, Wheeler, Jeanna M., Latimer, Caitlin S., Keene, C. Dirk, Kraemer, Brian C.
Publicado en Acta Neuropathol Commun (2021)

Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury

por Dohi, Kenji, Kraemer, Brian C., Erickson, Michelle A., McMillan, Pamela J., Kovac, Andrej, Flachbartova, Zuzana, Hansen, Kim M., Shah, Gul N., Sheibani, Nader, Salameh, Therese, Banks, William A.
Publicado 2014

The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

por Liachko, Nicole F., McMillan, Pamela J., Strovas, Timothy J., Loomis, Elaine, Greenup, Lynne, Murrell, Jill R., Ghetti, Bernardino, Raskind, Murray A., Montine, Thomas J., Bird, Thomas D., Leverenz, James B., Kraemer, Brian C.
Publicado en PLoS Genet (2014)

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

por Korvatska, Olena, Leverenz, James B., Jayadev, Suman, McMillan, Pamela, Kurtz, Irina, Guo, Xindi, Rumbaugh, Malia, Matsushita, Mark, Girirajan, Santhosh, Dorschner, Michael O., Kiianitsa, Kostantin, Yu, Chang-En, Brkanac, Zoran, Garden, Gwenn A., Raskind, Wendy H., Bird, Thomas D.
Publicado en JAMA Neurol (2015)

Blast Exposure Causes Dynamic Microglial/Macrophage Responses and Microdomains of Brain Microvessel Dysfunction

por Huber, Bertrand R., Meabon, James S., Hoffer, Zachary S., Zhang, Jing, Hoekstra, Jake G., Pagulayan, Kathleen F., McMillan, Pamela J., Mayer, Cynthia L., Banks, William A., Kraemer, Brian C., Raskind, Murray A., McGavern, Dorian B., Peskind, Elaine R., Cook, David G.
Publicado en Neuroscience (2016)

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation

por Liachko, Nicole F., Saxton, Aleen D., McMillan, Pamela J., Strovas, Timothy J., Currey, Heather N., Taylor, Laura M., Wheeler, Jeanna M., Oblak, Adrian L., Ghetti, Bernardino, Montine, Thomas J., Keene, C. Dirk, Raskind, Murray A., Bird, Thomas D., Kraemer, Brian C.
Publicado en Acta Neuropathol (2016)

High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration

por Wheeler, Jeanna M., McMillan, Pamela J., Hawk, Michele, Iba, Michiyo, Robinson, Linda, Xu, George J., Dombroski, Beth A., Jeong, Doori, Dichter, Marc A., Juul, Halvor, Loomis, Elaine, Raskind, Murray, Leverenz, James B., Trojanowski, John Q., Lee, Virginia M.Y., Schellenberg, Gerard D., Kraemer, Brian C.
Publicado en Acta Neuropathol Commun (2015)

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

por Wheeler, Jeanna M., McMillan, Pamela, Strovas, Timothy J., Liachko, Nicole F., Amlie-Wolf, Alexandre, Kow, Rebecca L., Klein, Ronald L., Szot, Patricia, Robinson, Linda, Guthrie, Chris, Saxton, Aleen, Kanaan, Nicholas M., Raskind, Murray, Peskind, Elaine, Trojanowski, John Q., Lee, Virginia M. Y., Wang, Li-San, Keene, C. Dirk, Bird, Thomas, Schellenberg, Gerard D., Kraemer, Brian
Publicado en Sci Transl Med (2019)