Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer’s Disease Is Associated with the Apolipoprotein E-ε4 Allele

Aβ is the major component of amyloid plaques characterizing Alzheimer’s disease (AD). Aβ accumulation can be affected by numerous factors including increased rates of production and/or impaired clearance. Insulin-degrading enzyme (IDE) has been implicated as a candidate enzyme responsible for the de...

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Autors principals: Cook, David G., Leverenz, James B., McMillan, Pamela J., Kulstad, J. Jacob, Ericksen, Sasha, Roth, Richard A., Schellenberg, Gerard D., Jin, Lee-Way, Kovacina, Kristina S., Craft, Suzanne
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2003
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851126/
https://ncbi.nlm.nih.gov/pubmed/12507914
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